About Washington University: Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics, neuroscience, and addiction.
Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.
Postdoctoral position: Focused on analyzing genetic variants associated with neurodevelopmental disorders using quantitative imaging and single cell genomics
The laboratories of Drs. Jeff Milbrandt and Rob Mitra invite highly motivated candidates to apply for positions as joint postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will develop research programs in Personalized Medicine aimed at revealing the pathogenic mechanisms of disease-associated variants via monitoring phenotypic changes of genetically perturbed iPSC-derived neurons and glia. The primary goal of our collaborative, multidisciplinary group is to understand the mechanistic basis of genetic abnormalities that result in neurodevelopmental, neuropsychiatric, or neurodegenerative disorders. To address these questions, we use a novel multi-omics approach that integrates high-throughput imaging and machine learning methods with CRISPR/Cas9 screens and saturation mutagenesis to answer central questions about the pathophysiology that results from genetic mutations in chromatin regulators, mitochondrial proteins, and metabolic enzymes. We interpret our experiments in the context of curated clinical phenotypes and validate key findings using banked patient samples. Multiple full-time positions are available immediately and are funded for up to three years, with the possibility of extension.
The ideal applicants will have:
1. PhD or MD/PhD in biological sciences or related fields
2. Experience in molecular biology or genomics.
3. Programming skills (Python and R) are preferred
4. Good communication skills
5. In addition, applicant must be able to visit St Louis for potential interviews
How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Drs. Jeff Milbrandt and Rob Mitra at MorphNSort@genetics.wustl.edu.
Postdoctoral position: To develop an inducible molecular memory system to record transient states of CNS cells.
The laboratories of Rob Mitra and Joe Dougherty invite mature, highly motivated candidates to apply for positions as joint postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will develop and apply methods based on the novel ‘Calling Cards’ technology that is able to record the genome-wide interactions of any DNA-binding protein (e.g. a specific transcription factor, or a general transcriptional mediator), creating a permanent molecular memory of all binding events that occur at a given moment or epoch. This technology allows transient molecular interactions to be captured non-destructively, during a controlled window in time, and then read out at a later point in time. This methodology has been developed in vitro, and successful applicants will adapt the technology for use in the brain to provide the community with a versatile toolbox that can be applied to a number of outstanding problems.
Multiple full-time positions are available immediately and are funded for three years, with the possibility of extension.
The ideal applicants will have:
- PhD or MD/PhD in biological sciences or related fields.
- Experience in molecular biology or genomics.
- Candidates with programming skills will be given priority (Python and R are preferred).
- Good spoken and written communication skills.
- In addition, applicant must be able to visit St Louis for potential interviews without visa application.
How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Drs. Rob Mitra and Joe Dougherty at rmitra@wustl.edu, jdougherty@genetics.wustl.edu.
Additional Positions Available:
- There are positions available for graduate students interested in experimental and/or computational biology.
To apply for a position, please send a cover letter describing your research interests, CV, and three letters of reference to:
Prof. Rob Mitra
Department of Genetics
Washington University
School of Medicine
4515 McKinley
Campus Box 8510
St. Louis, MO 63108
Email: rmitra[at]genetics.wustl.edu
Note to applicants for postdoctoral positions: please apply a minimum of three months in advance of when you would be available to start work on a full-time basis.